Exercise and the immune system

How does exercise affect the immune system?
When you exercise regularly, there are a number of health benefits that come with it. Your heart gets stronger and is able to pump more blood throughout your body when you exercise. Your lungs get better equipped at handling oxygen and providing it to your organs and to the rest of your body (and remember that cancer hates oxygen!). Your muscles also get stronger as you use them more often. And very important: your lymph system gets moving. Doctors have found that exercise can boost your immune system by providing a boost to the cells in your body that are assigned to attack bacteria. These cells appear to work more slowly in people who don’t exercise than in those that do. As a result, if you exercise, your immune system is better equipped to handle pathogens that could cause you to become sick, or boost your immune system if you already have an illness.

Why is Nagalase important?

1. Nagalase causes immunodeficiency. Nagalase blocks production of MAF, thus preventing the immune system from doing its job. Without an active immune system, cancer and viral infections can grow unchecked.
2. As an extremely sensitive marker for all cancers, Nagalase provides a powerful system for early detection.
3. Serial Nagalase testing provides a reliable and accurate method for tracking the results of any therapeutic regimen for cancer, AIDS, or other chronic viral infection.

Using Nagalase to screen for cancer & viruses

In the (hopefully not-too-distant) future, once Nagalase testing and GcMAF are available, all people at risk of cancer—i.e., everyone over the age of 40—will get an annual Nagalase test along with their other routine blood tests (complete blood count, comprehensive metabolic panel, vitamin D, lipid panel, etc.).

Nagalase is remarkably efficient

Because it is an enzyme—a catalyst—Nagalase performs this malicious ritual over and over and over again, and each time it comes away unscathed and unchanged. One Nagalase molecule can thus destroy a huge quantity of Vitamin D Binding Protein molecules.

Using Nagalase to track effectiveness of cancer & viral therapy

The more cancer cells present in the body, the more Nagalase they generate. Thus, Nagalase is the perfect marker for determining response to cancer therapies because, in a given patient, tumour burden will always be proportional to the Nagalase level.

Testing for Nagalase

The test measures the activity of  alfa-N-acetylgalactosaminidase (nagalase) in blood.  Nagalase is an extracellular matrix-degrading enzyme that is (increased) secreted by cancerous cells in the process of tumour invasion. It also is an intrisic component of envelope protein of various virions, such as  HIV and  the influenza virus. It is secreted from virus-infected cells..1,3,4

Nagalase the basics

Nagalase occurs naturally in the intestines where it breaks down glyocproteins in our food.

Nagalase is also produced in quantities by cancers, viruses & bacteria to break down a specific glycoprotein in our blood – Vitamin D Binding (Glyco)Protein.  Nagalase breaks VDBP at a triage of sugars that are required to activate our immune cells, thus elevated levels of Nagalase in the blood can lead to immune-suppression where after cancers and pathogens can grow unchecked.

Because it is an enzyme—a catalyst—Nagalase performs this malicious ritual over and over and over again, and each time it comes away unscathed and unchanged. One Nagalase molecule can thus destroy a huge quantity of Vitamin D Binding Protein molecules.

Nagalase has no natural enemies. No bodily process, no drug, no treatment could outsmart this diabolical killer. Until Dr. Nobuto Yamamoto researched and published Nagalase, we had no idea as to the actual cause of the immune shutdown that allows cancers and viruses grow unchecked.

Pathogenic significance of Nagalase activity found in the hemagglutinin of influenza virus

Serum vitamin D3-binding protein (Gc protein) is the precursor for the principal macrophage activating factor (MAF). The precursor activity of serum Gc protein was reduced in all influenza virus-infected patients.

Nagalase – A Near-Universal Cancer Marker?

Even though further clarification is required regarding the structure and generation of GcMAF, Yamamoto’s body of work has given rise to two key propositions that may have extraordinary importance if sustained by future research: namely, that serum nagalase can serve as a virtually universal marker for cancer, and that parenteral administration of pre-formed GcMAF can exert a profound immunostimulant effect in cancer patients, enabling the effective control and eradication of many cancers when they are in a micrometastatic or very early nascent form.